A journey into the world of bioinformatics


PANDORA-seq – New RNA-Sequencing Method to improve small RNA detection

Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing (PANDORA) is a new RNA sequencing method developed by scientists from the University of California, Riverside (UCR), and published in the journal Nature Cell Biology in a paper titled “PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications.” Pandora-seq uses combinatorial enzymatic treatment to remove […]

How to retrieve one or more biological sequences?

One of the most frequent operations I do during the day is the search and recovery of biological sequences of interest. So I think it is necessary to talk to you about how this can be done, especially for novices, and therefore be able to “play” with some recovered genes or proteins. I remember that […]

scGNN – Novel graph neural network framework for single-cell RNA-Seq analyses

Researchers at the University of Missouri and Ohio State University published a paper two days ago in Nature communication in which they claim to have created a new way to analyze data obtained from single-cell RNA sequencing using deep learning. Deep learning has been making great strides in recent years and is entering more and […]

What is a gene?

You know recently I have often sat in front of the computer intent on writing something more technical and therefore to present you more in-depth bioinformatics analyzes but I have always found myself in difficulty because I realize that sometimes to better understand a certain type of bioinformatics analysis it is also necessary to know […]


Hi! How are you? I hope so. I have decided to delight you with a new article that will go straight into the column “Files in bioinformatics”, in which I talk about the most common and important file types used by bioinformaticians. In fact, today we talk about SAM file, or Sequence Alignment Map file, and its cousin BAM […]

How does bioinformatics investigate?

As I have already said several times here on the blog, bioinformatics allows us to answer questions and understand biological phenomena by analyzing the data obtained from experimental tests performed in the laboratory. But what are the general methods by which bioinformatics analyzes data in order to achieve the desired knowledge? There are two main […]

FASTQ does it better!

Hi. I haven’t blogged in a long time. Unfortunately, I have about six months of fire. In fact, between the thesis and the last exams of the master’s course, finding time to study and bring material here on the blog has become difficult. But don’t be afraid. After July we at Bioinformaticamente will try to […]


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